Metal Complexes in Biology and Medicine (Part- Mercury (II) / Nickel (II) / Lead (II) – Isoleucine Binary Complexes)

Abstract

Present electrophoretic method is based upon the migration of a spot of metal ions on a paper strip at different pHs of background electrolyte.  A graph of pH against mobility gives information about the binary complexes and permit to calculate their stability constants.  The first and second stability constants of [Hg (II) – isoleucine], [Ni (II) – isoleucine] and [Pb (II) – isoleucine] complexes were found to be (8.80 ± 0.02, 7.52 ± 0.05), (7.27 ± 0.01, 5.86 ± 0.03 and (7.17 ± 0.05, 3.32 ± 0.09) for Hg (II), Ni (II) and Pb (II) complexes, respectively at 0.01 M ionic strength and a temperature of 35°C.

The study objectives of present work are (i) Look for the formation of binary complexes between   the divalent metal ions and isoleucine (ii) Determine the stability constants of complexes formed (iii) To explore the possibility on applications of said binary complexes in Biology and medicine