Investigating the Influence of pH on Drug Release from Zidovudine Matrices Containing Different Grades of Hydroxypropyl Methyl Cellulose

Abstract

The current study investigates the impact of a multimedia dissolution profile on the drug release of zidovudine-containing sustained-release hydrophilic matrices using a variety of hydroxypropyl methylcellulose grades. Zidovudine, the first anti-HIV drug to receive FDA approval for clinical use, is widely used to treat AIDS, either alone or in combination with other antiviral drugs. To sustain the release of the medication, matrices were created utilising a combination of several grades of HPMC, namely HPMCK4M and HPMCK15M. In-vitro multimedia dissolution studies were carried out in order to mimic the in-vivo situation. The pH/buffer is chosen based on the drug's exposure from the stomach to the intestine/colon. The research ensures that pH changes have an effect on drug dissolution and release for absorption. Matrices also provide quite regulated release of the drug zidovudine over an extended period of time.