Study on Synthesis and Biological Activities of Novel 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidines

Abstract

Aiming to synthesize new anti-inflammatory 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidine 5 from aminocyanopyrazole, a forthright method has been developed. It is for their anti-inflammatory, gastroprotective, analgesic, antioxidant and anticandidal activities that these compounds were screened. The investigation of the structure-activity relationships have brought about the choice of compound 6-(4-methoxyphenyl)-3-methyl-1,7-dihydropyrazolo[3,4-d]imidazo[1,2-f]pyrimidine, 5a, which revealed the most powerful activities. All novel compounds’ structures were expounded using IR, ¹H NMR, ¹³C NMR and HRMS.