Research on Synthesis and Anti Convulsant Activity of Novel Oxadiazole Substituted Phenothiazine Derivatives

Authors

  • N. S. Dighe Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India.
  • A. A. Bankar Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India.
  • D. S. Musmade Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopergaon, MS, India.
  • S. A. Nirmal Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni, MS, India.

DOI:

https://doi.org/10.9734/bpi/cacb/v4/1783F

Keywords:

Anticonvulsant activity, strychnine induced model, thiosemicarbazide induced model, 4-amino pyridine induced model, neurotoxicity screening

Abstract

The purpose of this research is directed towards the synthesis and evaluation of novel agents for the treatment of a variety of neurological disorders. In the past, the phenothiazine nucleus has been thoroughly investigated for various biological activities. The oxadiazole substituted phenothiazine has piqued interest as a potential treatment for a variety of neurological disorders. In light of these findings, researchers attempted to synthesise substituted phenothiazine and test them for anticonvulsant activity. Strychnine and 4-aminopyridine mediated models were used to test the anti-convulsant efficacy of synthesised compounds. These compounds can be used for ligand based drug designing purpose by which exact molecular mechanism responsible for showing anti-convulsant effect can be explored in future.

Published

2021-05-05

How to Cite

N. S. Dighe, A. A. Bankar, D. S. Musmade, & S. A. Nirmal. (2021). Research on Synthesis and Anti Convulsant Activity of Novel Oxadiazole Substituted Phenothiazine Derivatives. Current Advances in Chemistry and Biochemistry Vol. 4, 54–60. https://doi.org/10.9734/bpi/cacb/v4/1783F

Issue

Current Advances in Chemistry and Biochemistry Vol. 4

Section

Chapters