Nguyen Thi Trieu
Clinical Drug Research and Development Department under Saigon Biopharma Company, Vietnam.

Tran Minh Duc
Clinical Drug Research and Development Department under Saigon Biopharma Company, Vietnam.

Tran Minh Cam Tu
Clinical Drug Research and Development Department under Saigon Biopharma Company, Vietnam.

ISBN 978-81-960551-9-6 (Print)
ISBN 978-81-960551-8-9 (eBook)
DOI: 10.9734/bpi/mono/978-81-960551-9-6

This book belongs to the medical and medical sciences fields. The authors wanted to publish the achievements made in treating certain chronic diseases. Authors' contributions include infertility due to azoospermia, uterine fibroids and pregnancy, strengthening antibodies in COVID-19 patients with immunodeficiency, cirrhosis, and hepatocellular carcinoma. These achievements can be applied to the treatment of some other chronic diseases such as hepatitis B, hepatitis C, HIV, AIDS, and some other cancers at an early stage. This book contains many useful, authentic materials and information for students, researchers, and scholars in the medical and medical sciences fields.


Media Promotion


Advances in Treating Chronic Disease

Nguyen Thi Trieu, Tran Minh Duc, Tran Minh Cam Tu

Advances in Treating Chronic Disease, 28 December 2022, Page 1

Since ancient times, in the medical field, people have taken advantage of natural substances to cure diseases. Today, modern medicine is constantly developing, inheriting from the ancients to continue to conduct new research and produce effective treatment products for several diseases that are considered chronic today.

The compositions mentioned in the book have successfully treated a number of supposedly chronic diseases, such as cirrhosis and hepatocellular carcinoma caused by HBV and HCV infections; increased antibodies against COVID-19 in immunocompromised patients, infertility due to orchitis, the testicles are unable to produce spermatozoon, help the testicles complete five successive stages: (1) spermatogonia, (2) primary spermatocytes, (3) secondary spermatocytes, (4) spermatids, and (5) spermatozoon; protecting the fetus, and helping the fetus to develop to full term in a uterus with multiple fibroids. The selective compositions act on the patient's immune system, helping the body to resist harmful effects from the environment. Thanks to the natural substances: Flavonoids; Ascorbic Acid; Pyridoxal phosphate; Pregnenolone, they act as anti-inflammatory agents, enzymes that catalyze the body's chain reactions, as well as natural hormones. They have corrected chronic inflammatory disorders, tumors that grow out of control, causing a number of dangers to the patient's health. Research has shown that flavonoids and vitamins such as Ascorbic Acid, Pyridoxal phosphate, and Pregnenolone mentioned in this book have the necessary biological activity. They have a high impact potential, help the body to regulate, inactivate viruses, dissolve inflammatory tissue, prevent and destroy cancer cells at an early stage.

With practical evidence, the book will give readers an overview of the potential that needs to be discovered from nature to serve human life.

A Discovery Helps the Testes to Re-Establish the Spermatogenesis

Nguyen Thi Trieu, Tran Minh Duc, Tran Minh Cam Tu

Advances in Treating Chronic Disease, 28 December 2022, Page 2-26

Research to develop a new, natural-derived formulation that eliminates inflammatory tissues and regenerates new tissues of the lobules, epitheliums of the tubules, and connective tissues surrounding the seminiferous tubules in the testes. It restores Leydig cells and Sertoli cells function (because the inflamed testicles were unable to perform spermatogenesis).

A new natural origin product, achieving more than 80% efficiency in spermatogenesis in the seminiferous tubules. This method opens up hope for cases of infertility caused by the inability of spermatogonia to develop into mature sperm.

Treatment of Uterine Fibroid in Pregnancy

Nguyen Thi Trieu, Tran Minh Duc, Tran Minh Cam Tu

Advances in Treating Chronic Disease, 28 December 2022, Page 27-46

Develop a treatment to help pregnant women carry and give birth normally when there is multiple fibroids in the uterine muscles. Uterine fibroids are very common and can be detected during the pregnancy of reproductive-age women. Uterine fibroids usually grow very quickly in the first 3 months of pregnancy.

Clinically it shows that:

  • Uterine fibroids are associated with abundant and prolonged menstruati
  • The woman's ability to get pregnant and give birth is fraught with difficultie Fibroids increase the rate of spontaneous abortion, premature birth, placental abruption, labor disorders, cesarean section, and postpartum hemorrhage due to poor uterine contraction. Pain is the most common complication of uterine fibroids during pregnancy.
  • The problem is finding a way to make the fibroids stop growing and degenerate, to create safety for the fet There will be many complications for pregnant women and fetuses if not managed and intervened early. The selected drugs have anti-tumor effects without side effects detected, which can cause fibroids to soften and lie evenly in the uterine muscles. The fact that the ingredients act well in the process of fibroid degeneration, protecting pregnant women and the fetus has proven to be successful in the treatment of uterine fibroids during pregnancy. The fetus will adjust itself well in the uterine cavity, not being occupied by fast-growing tumors encroaching on the uterine cavity.
  • Fibroids will stop growing and disappear during pregnancy if pregnenolone and Coenzyme Pyridoxal Phosphate are used for early interventi The course of treatment helps the fetus to develop normally. These women will have a normally developing uterus through the stages of pregnancy. Their uterus is egg-shaped, the uterine muscles are only a few millimeters thicker than normal uterine muscles, and the placenta adheres tightly to the lining of the uterus with adequate perfusion like other normal pregnancies.
  • Calculate a sufficient amount of Pregnenolone and Coenzyme Pyridoxal Phosphate to apply to the degeneration of fibroi These components will soften uterine fibroids and remove the bulk-forming texture. Pregnenolone is produced in the adrenal glands and central nervous system. Pregnenolone is synthesized from Cholesterol and it is a precursor of Progesterone, Estrogen and dehydroepiandrosterone (DHEA). In some people, Pregnenolone will gradually decrease with age leading to an imbalance between Progesterone, Estrogen. According to studies, this imbalance is responsible for the abnormal growth and shaping of the connective tissue of uterine muscle fiber cells, creating uterine fibroids. Pregnenolone supplements are necessary for reproductive age women and pregnant women with uterine fibroids because fibroids will grow rapidly, occupied the fetuses' space. There will be many problems that need to be intervened during pregnancy and during childbirth, with the risk of miscarriage or premature birth.

Pregnenolone, and Coenzyme Pyridoxal Phosphate are included in the composition used to treat uterine fibroids during pregnancy. They help to balance the metabolism of steroid hormones. The composition present in the body will inhibit the abnormal growth of the structure of uterine muscle fibers, soften the muscle fibers and connective tissue in the fibroid tumor, return to its normal structure, merge into the uterine muscles. The uterus returns to its normal state. The fetus will develop naturally until the pregnancy reaches full term.

Flavonoids in the Treatment of Cirrhosis and Liver Cancer

Nguyen Thi Trieu, Tran Minh Duc, Tran Minh Cam Tu

Advances in Treating Chronic Disease, 28 December 2022, Page 47-63

The aim is to use flavonoids to develop a new formula that regenerates fibrotic hepatocellular epithelium, clears scar tissue, stops progression to hepatocellular carcinoma, and prevents the recurrence of hepatocellular carcinoma. The flavonoids are used to treat compensated cirrhosis (Child Pugh \(\le\) 6) and early stage hepatocellular carcinoma (Hcc) (when the tumor is small in size (< 3cm) and less than 3 tumors). The selective flavonoids in combination with pregnenolone, ascorbic acid, pyridoxine 5-phosphate, and L-arginine are effective in cutting off the liver cells' chronic inflammatory chain and preventing fibrosis. Kupffer cells are not activated to destroy liver cells and do not activate the activation of hepatic stellate cells (HSCs), which help liver enzymes stabilize without disturbing the function of the liver. The process of apoptosis and regeneration of liver cells has helped the liver recover well. The ingredients acted on the hepatocyte protection and regeneration cycles. The composition has demonstrated therapeutic efficacy over 5 years of follow-up with patients. The ascorbic acid, pyridoxine 5-phosphate, pregnenolone, L-arginine, flavonoids, and iso-flavonoids have demonstrated the safety of the composition during treatment. The ingredients are found in nature and are on the FDA's list of approved medicinal substances. The trial was performed retrospectively on people who had been diagnosed with compensated cirrhosis and with or without attachment hepatocellular carcinoma. Through observing all patients using the ingredients contained in the study for different therapeutic purposes beforehand. No cases of severe progression of cirrhosis nor recurrence of hepatocellular carcinoma have been detected.

The use of ascorbic acid, pyridoxine 5-phosphate, pregnenolone, L-arginine, flavonoids, and iso-flavonoids in treatment has helped to regenerate liver cells completely, helping the physiological and biochemical functions of the liver to be stabilized, helping the liver to restore its function in the body.

Sars-CoV-2 (COVID-19)? A New Discovery that Helps the Body Make Its Own Igg Efficiently

Nguyen Thi Trieu, Tran Minh Duc, Tran Minh Cam Tu

Advances in Treating Chronic Disease, 28 December 2022, Page 64-80

The purpose of this research is to develop a new formulation that neutralizes spike glycoproteins and destroys the shell containing these spikes, including the core containing the genetic material of the virus. Spike glycoproteins are the cause of disseminated intravascular coagulation, damage to organ tissues, create a violent inflammatory response when foreign objects enter the body, cause necrosis of organ tissues and lead to death or left with severe sequelae after infection with Sars-CoV-2. The product is effective in eliminating viruses early, not allowing them to have enough time to multiply. This new treatment formulation does not depend on the mutated forms of Sars-CoV-2. The formulation should be applied early when exposure is suspected or in high-risk areas to prevent and reduce mortality as well as reduce health damage to patients after infection. The product is safe, 100% effective, and has been retrospectively accounted for in individuals diagnosed with natural or acquired immunodeficiency who have been identified with underlying diseases.

Observationally, all of the patients who had previously used the ingredients in the formulation for various therapeutic purposes had no known cases of Sars-CoV-2 infection, nor when they are living in an epidemic area.

All of these patients, when they had close contact with their infected member in the family, were safe and not infected, while all the rest of their family members were infected to some different degree. The formulation helps the body make its own IgG efficiently, easily eliminating Sars-CoV-2.