Overview of Flow Cytometry Techniques for Immunophenotyping in B-Cell Lymphoproliferative Disorders

Authors

  • B L T Balasuriya Department of Haematology, Sri Jayewardenepura General Hospital, Thalapathpitiya, Nugegoda, Sri Lanka.
  • C S Moonesinghe Department of Pathology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
  • S S N Fernando Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
  • T D C P Gunasekara Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
  • S Jayakody Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
  • C C Kariyawasan Department of Haematology, Sri Jayewardenepura General Hospital, Thalapathpitiya, Nugegoda, Sri Lanka.

DOI:

https://doi.org/10.9734/bpi/acmms/v7/3477

Keywords:

Low cytometry, immunophenotyping, lymphoma, BCLPD, B-NHL

Abstract

B-cell lymphoproliferative disorders (BCLPDs) encompass a diverse range of neoplasms with immunophenotypic profiles. This review discusses the classification of BCLPDs based on flow cytometric immunophenotyping, focusing on markers such as CD5, and CD10. Key subtypes, including CLL, MCL, and DLBCL, are analyzed for diagnostic and prognostic insights. Advanced flow cytometry techniques aid in subtype differentiation, guiding personalized treatment approaches and improving outcomes. Global variations and diagnostic challenges are also highlighted, supporting a comprehensive understanding of BCLPDs.

Downloads

Published

2024-12-20

How to Cite

B L T Balasuriya, C S Moonesinghe, S S N Fernando, T D C P Gunasekara, S Jayakody, & C C Kariyawasan. (2024). Overview of Flow Cytometry Techniques for Immunophenotyping in B-Cell Lymphoproliferative Disorders. Achievements and Challenges of Medicine and Medical Science Vol. 7, 68–83. https://doi.org/10.9734/bpi/acmms/v7/3477

Issue

Achievements and Challenges of Medicine and Medical Science Vol. 7

Section

Chapters